On Sept. 6, 1901, a Michigan native shot and killed President William McKinley during his visit to the Pan American Exhibition in Buffalo, N.Y. Leon F. Czolgosz, an anarchist from Michigan living in Cleveland, believed killing the president would put an end to the American government. It is unclear which Michigan city Czolgosz was from and when he became interested in radical politics, but his two shots from a revolver did cause McKinley to die eight days after the incident.
Source: Michigan Every Day