Michigan State 41, Northwestern 38 (Oct. 21, 2006) – 35 points
Via Sporting News: Under then-coach John Smith, Michigan State engineered the largest comeback in college football history against Northwestern. The Spartans opened the game with a field goal before the Wildcats tallied 38 unanswered to take a 35-point advantage with 9:54 left in the third quarter. But on their next possession, Spartans quarterback Drew Stanton led a nine-play, 65-yard drive to start shifting momentum back in his team’s favor. Over the next 22 minutes, Michigan State’s defense forced four three-and-outs and two interceptions to give the Spartans a chance to kick a game-winning field goal with 13 seconds remaining.